en پژوهشی اصيل Original Research <strong>Aims:</strong> This study aimed to determine the acupressure effect on anxiety in infertile women undergoing <em>in vitro</em> fertilization/intracytoplasmic insemination treatments.<br> <strong>Materials & Methods:</strong> The present study is a randomized controlled trial of infertile women undergoing <em>in vitro </em>fertilization/intracytoplasmic insemination treatment. It was performed at Milad <em>in vitro </em>Fertilization Center, Mashhad University of Medical Sciences, from September 2015 to August 2016. The sample size was 144 participants. The participants were randomly divided into three groups of real acupressure, sham acupressure, and control using a Fleiss randomization table. Acupressure points were P6 and H7 on the participant&rsquo;s hands. Beck Anxiety Inventory was used for assessing anxiety and a demographic questionnaire. Data were analyzed through paired samples t-test, Chi-square test, Fisher exact, One-way analysis of variance, Kruskal Wallis test, General Linear Model, and Multinomial logistic by SPSS 16.<br> <strong>Findings:</strong> The mean age of women was 30.84&plusmn;5.34. There was a significant difference in anxiety reduction rate in all groups (p<0.001). <span dir="RTL"></span><br> <strong>Conclusion:</strong> The acupressure intervention at the points of P6 and H7 on the participant&rsquo;s hands reduces anxiety. Therefore, due to the effect of anxiety on the pregnancy rate in women undergoing <em>in vitro </em>fertilization/intracytoplasmic insemination, acupressure in these women is recommended.<br> &nbsp; Acupressure,Anxiety,Infertility,Women,Pregnancy Rate, 181 186 http://jccs.yums.ac.ir/browse.php?a_code=A-10-145-1&slc_lang=en&sid=1 T. Khadivzadeh 10031947532846005622 10031947532846005622 No Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran M. Hassanzadeh Bashtian m.h.bashtian@gmail.com 10031947532846005623 10031947532846005623 Yes Department of Midwifery, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran Sh. Badiee Aval 10031947532846005624 10031947532846005624 No Acupuncture Department, School of Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Iran H. Esmaily 10031947532846005625 10031947532846005625 No “Health Sciences Research Center” and “Department of Biostatistics and Epidemiology, School of Health”, Mashhad University of Medical Sciences, Mashhad, Iran