en پژوهشی اصيل Original Research <strong>Aims:</strong> This study aimed to determine the antifungal susceptibility profile of <em>Candida</em> spp. with different sources.<br> <strong>Methods</strong>: This descriptive study was conducted in the Department of Medical Mycology of Yasuj, Iran, from 2018 to 2019. Seventy-six <em>Candida</em> isolates recovered from different samples were used for antifungal profiles. <em>Candida</em> spp. isolates were identified at the species level based on molecular methods. The antifungal susceptibility tests with fluconazole, voriconazole, itraconazole, clotrimazole, amphotericin B, nystatin, and caspofungin were assessed according to the Clinical and Laboratory Standards Institute broth microdilution method.<br> <strong>Findings:</strong> Our study showed that all isolates species were sensitive to antifungal drugs except for 3 (3.9%) isolates resistant to fluconazole. Among the <em>In vitro </em>activity of triazoles against all isolates tested, voriconazole had the lowest minimum inhibitory concentration ranges of 0.5-0.015&micro;g/ml. According to the minimum inhibitory concentration of 50%, amphotericin B (0.25&mu;g/ml) and nystatin (0.0625&mu;g/ml) was the most active polyenes against other Candida species.<br> <strong>Conclusion:</strong> Generally, the clinical correlation between the minimum inhibitory concentration value of different antifungals and different <em>Candida</em> spp. isolates are necessary because the resistance profile of <em>Candida</em> spp. is varied and dependent on the different variables. Antifungal Agents,Candida,Candidiasis,in vitro, 195 199 http://jccs.yums.ac.ir/browse.php?a_code=A-10-147-1&slc_lang=en&sid=1 M. Gharghani 10031947532846005631 10031947532846005631 No Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran R. Rezaei-Matehkolaei 10031947532846005632 10031947532846005632 No Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Gh. Shokoohi 10031947532846005633 10031947532846005633 No Department of Medical Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran J. Taghavi 10031947532846005634 10031947532846005634 No Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran S. Nouripour-Sisakht nooripoor8561@gmail.com 10031947532846005635 10031947532846005635 Yes Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran