Journal of Clinical Care and Skills
مجله مهارتها و مراقبتهای بالینی
J Clinic Care Skill
Medical Sciences
http://jccs.yums.ac.ir
1
admin
2645-7687
10.58209/jccs
en
jalali
1401
9
1
gregorian
2022
12
1
3
4
online
1
fulltext
en
Association between the ACE I/D Variant and COVID-19 Susceptibility and Severity; a Meta-Analysis
تخصصي
Special
پژوهشي
Research
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:"><span style="color:black">Aims:</span></span></b><b> </b><span cambria="" style="font-family:"><span style="color:black">Several studies investigated the association of ACE I/D polymorphism with the risk and severity of COVID-19 infection. However, the information in each of the published studies is limited, and the results were inconsistent or even contradictory. Accordingly, this meta-analysis evaluated the association between ACE I/D polymorphism and COVID-19 susceptibility and severity. </span></span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:"><span style="color:black">Materials & Methods:</span></span></b><span cambria="" style="font-family:"><span style="color:black"> Two investigators independently searched the PubMed, Embase, Google Scholar, Scopus, and Science Direct databases. Five studies including 1029 cases and 3561 controls were retrieved to evaluate the association between ACE I/D polymorphism and the risk of COVID-19. Furthermore, a meta-analysis of the correlation between the ACE I/D variant and the severity of infection covered 5 case-control studies, including 264 sever-cases and 447 mild cases. </span></span></span></span></span><br>
<span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:"><span style="color:black">Findings:</span></span></b><span cambria="" style="font-family:"><span style="color:black"> There was no association between the ACE I/D variant in all genetic models and COVID-19 susceptibility. However, our analysis revealed that there was a significant association between ACE I/D variant in the allele contrast (95% CI=0.5291-0.8353; p<0.001), recessive (95% CI=0.4268-0.9172; p=0.01) and dominant (95% CI=0.3974-0.8092; p=0.001) models and severity of COVID-19. </span></span></span></span></span><br>
<b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:black">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:black"> ACE I/D polymorphism is associated with the severity of COVID-19 infection. There is no association between the ACE I/D variant in all genetic models and COVID-19 susceptibility. </span></span></span>
ACE, I/D Polymorphism, COVID-19, Meta-Analysis
167
170
http://jccs.yums.ac.ir/browse.php?a_code=A-10-195-1&slc_lang=en&sid=1
SH.
Nikooe
shekufeh.nikouei75@gmail.com
10031947532846002584
10031947532846002584
No
Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
H.
Ghasemi
hasanghaseme@gmail.com
10031947532846002585
10031947532846002585
No
Department of Basic Sciences, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
M. R.
Zarei
mohammadrezazarei620@gmail.com
10031947532846002586
10031947532846002586
No
Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran
H.
Vakilpour
Hossein.vakilpour92@yahoo.com
10031947532846002587
10031947532846002587
No
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
B.
Alipoor
behnaalipoor@gmail.com
10031947532846002588
10031947532846002588
Yes
Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran