en پژوهشی اصيل Original Research <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Aims:</span></b><b> </b><a name="_Hlk119928193"><span cambria="" style="font-family:">Lamiaceae family are compromised the majority of species of the family have essence that was used for the nutritional, cosmetic, and pharmaceutical industry. This study aimed to investigate the chemical composition of essential oil from aerial parts of <i>Bollota aucheri </i>with its antibacterial and antifungal activity of it compared with fluconazole. </span></a></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Materials & </span></b><b><span cambria="" style="font-family:">Methods: </span></b><span cambria="" style="font-family:">This clinical laboratory research was conducted on the flowering aerial parts of B. aucheri that were collected during 2020-2021 from Zagros mountains in Kohgiluyeh and Boyer-Ahmad province, Iran. The essential oil of this plant was tested for antibacterial and antifungal properties and compared with fluconazole.&nbsp; The chemical composition of the essential oil was analyzed by GC/MS (Gas Chromatography Mass Spectrometry) and the antifungal activity of the plant essential oil was compared with fluconazole.</span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Findings:</span></b><span cambria="" style="font-family:"> Generally, &beta;-Caryophyllene was the main compound of <i>B. aucheri</i> essential oil. The minimum inhibitory concentration (MIC) of the essential oil of the fruit of <i>B. aucheri</i> and fluconazole were 0.078&micro;l/ml and 1&micro;l/ml for Candida albicans, 0.078&micro;l/ml and 0.5&micro;l/ml for <i>C. glabrata</i>, and 0.078&micro;l/ml and 0.178&micro;l/ml for <i>C. parapsilosis</i>, respectively. </span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span cambria="" style="font-family:">Conclusion:</span></b><span cambria="" style="font-family:"> The essential oil of <i>B. aucheri</i> could be used as a bactericidal and fungal alternative to antibiotics against microorganisms. <a name="_Hlk137586591">Antifungal activity of <i>B. aucheri</i> essential oil is stronger than fluconazole</a></span><span cambria="" lang="EN" style="font-family:">.</span><span style="font-family:"Cambria","serif""></span></span></span></span><br> &nbsp; Ballota aucheri,Essential Oils,Candida albicans,Candida glabrata,Candida parapsilosis,Lamiaceae Family,Fungal Infections, 27 31 http://jccs.yums.ac.ir/browse.php?a_code=A-10-178-3&slc_lang=en&sid=1 M. Gharaghani maralgharaghani@gmail.com 10031947532846004631 10031947532846004631 No ”Medicinal Plants Research Center” and “Department of Medical microbiology, School of Medicine”, Yasuj University of Medical Sciences, Yasuj, Iran Z. Ashrafzade danaei.nazanin@gmail.com 10031947532846004632 10031947532846004632 No ”Medicinal Plants Research Center” and “Department of Medical microbiology, School of Medicine”, Yasuj University of Medical Sciences, Yasuj, Iran D. Razmjoue d.razmjoue@gmail.com 10031947532846004633 10031947532846004633 No ”Medicinal Plants Research Center” and “Department of Medical microbiology, School of Medicine”, Yasuj University of Medical Sciences, Yasuj, Iran H. Sadeghi Mansourkhani h_sadeghi_m@yahoo.com 10031947532846004634 10031947532846004634 No ”Medicinal Plants Research Center” and “Department of Medical microbiology, School of Medicine”, Yasuj University of Medical Sciences, Yasuj, Iran M. Salahi marjansalahi114@gmail.com 10031947532846004635 10031947532846004635 No ”Medicinal Plants Research Center” and “Department of Medical microbiology, School of Medicine”, Yasuj University of Medical Sciences, Yasuj, Iran H. Yousefi Mehryan Hadi.yusefi91@gmail.com 10031947532846004636 10031947532846004636 No Shahid Jalil Hospital, Yasuj University of Medical Sciences, Yasuj, Iran T. Talaie Tahereh.talaie63@gmail.com 10031947532846004637 10031947532846004637 No Shahid Jalil Hospital, Yasuj University of Medical Sciences, Yasuj, Iran S. Nouripour-Sisakht nooripoor8561@gmail.com 10031947532846004638 10031947532846004638 Yes ”Medicinal Plants Research Center” and “Department of Medical microbiology, School of Medicine”, Yasuj University of Medical Sciences, Yasuj, Iran