en Health Care Delivery Health Care Delivery پژوهشی اصيل Original Research <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Aims</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">: </span></span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">Intraperitoneal CO₂ insufflation appears to be a risk factor for alterations in coagulation and liver function tests (LFT) following laparoscopic cholecystectomy. Therefore</span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">, </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">the present study was conducted with the aim of comparing the effect of low-pressure CO₂ intraperitoneal insufflation (12-15 mmHg), and high-pressure CO₂ intraperitoneal insufflation (16-20 mmHg) on the patient&#39;s coagulation status and liver function test after laparoscopic cholecystectomy.</span></span><span style="font-size:10.0pt"><span style="font-family:"Cambria",serif"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Materials & Methods:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> This randomized clinical trial consisted of 150 patients who were candidates for laparoscopic cholecystectomy and referred to Shahid Beheshti and Shahid Jalil Hospitals affiliated with Yasuj University of Medical Sciences, Iran in 2022-2023. </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">They were selected using the convenience sampling method and allocated </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">to</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:"> two different CO₂ insufflation pressure levels, either 12-15 or 16-20 mmHg by random sampling method (75 patients each). Coagulation profile including prothrombin time (PT), partial thromboplastin time (PTT), international normalized ratio (INR), bleeding time (BT)</span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">, and liver function tests such as AST (</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">Aspartate Aminotransferase)</span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">, ALT (</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">Alanine Transaminase)</span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">, ALP (</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">Alkaline Phosphatase)</span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">, total bilirubin (T.bili), and direct bilirubin (D.bili)</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:"> were measured and recorded in the night before the operation and 24 hours after the operation. The data was analyzed by SPSS 16 (p-value<0.05).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Findings:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> There was a significant increase in PT (p=0.035), and a decrease in BT (p=0.0001) in the group with </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">pressure levels of 16-20 compared to 12-15 mmHg after the intervention</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> T</span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">he level of </span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">intraperitoneal CO₂ insufflation </span></span><span lang="EN" style="font-size:10.0pt"><span cambria="" style="font-family:">has no effect on coagulation and liver. Therefore</span></span><span style="font-size:10.0pt"><span cambria="" style="font-family:">, CO₂pressure of 12-20 can be used safely in laparoscopic cholecystectomy surgeries.</span></span></span></span></span><br> &nbsp; Carbon Dioxide,Insufflation,Blood Coagulation Factor,Liver Function Test,Laparoscopic Cholecystectomy, 189 195 http://jccs.yums.ac.ir/browse.php?a_code=A-10-323-1&slc_lang=en&sid=1 M.B. Jahantab 10031947532846005183 10031947532846005183 No “Department of Surgery, School of Medicine” and “Shahid Beheshti Hospital”, Yasuj University of Medical Sciences, Yasuj, Iran A. Mohsenpour 10031947532846005184 10031947532846005184 No “Department of Surgery, School of Medicine” and “Shahid Beheshti Hospital”, Yasuj University of Medical Sciences, Yasuj, Iran Sh. Salaminia 10031947532846005185 10031947532846005185 Yes “Department of Surgery, School of Medicine” and “Shahid Beheshti Hospital”, Yasuj University of Medical Sciences, Yasuj, Iran S. Mehrabi Sisakht 10031947532846005186 10031947532846005186 No “Department of Surgery, School of Medicine” and “Shahid Beheshti Hospital”, Yasuj University of Medical Sciences, Yasuj, Iran N. Roustaei 10031947532846005187 10031947532846005187 No “Department of Biostatistics and Epidemiology, School of Health” and “Social Determinants of Health Research Center”, Yasuj University of Medical Sciences, Yasuj, Iran J.M. Malekzadeh 10031947532846005188 10031947532846005188 No Department of Nutrition, School of Health, Yasuj University of Medical Sciences, Yasuj, Iran M.J. Yavari Barhaghtalab 10031947532846005189 10031947532846005189 No “Department of Surgery, School of Medicine” and “Shahid Beheshti Hospital”, Yasuj University of Medical Sciences, Yasuj, Iran