en Diagnosis Skills Diagnosis Skills پژوهشی اصيل Original Research <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#44546a">Aims:</span></span></span></span></strong><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"> This study aimed to evaluate the possible beneficial effects of omega-3 and L-carnitine, as well as their combination, on individuals undergoing hemodialysis.</span></span><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#44546a">Materials & Methods:</span></span></span></span></strong><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"> This randomized clinical trial was conducted on 75 hemodialysis patients, divided into three groups (each 25 participants) using a randomized block method. The intervention groups received L-carnitine 250 mg tablets twice a day, one omega-3 capsule, 1000 mg per day, and L-carnitine 250 mg tablets twice a day along with one omega-3 capsule, 1000 mg per day, for three months. Lipid profiles and C-reactive protein levels were measured through laboratory tests before and after the intervention. The quality of life for kidney disease and quality of sleep were assessed using the Kidney Disease Quality of Life Questionnaire and the Pittsburgh Sleep Quality Index, respectively. Data were analyzed using SPSS 20 software.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:none"><span style="font-family:Calibri,sans-serif"><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#44546a">Findings:</span></span></span></span></strong><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"> </span></span></span></strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif">The administration of L-carnitine (500 mg per day) did not demonstrate a beneficial effect on high-density lipoprotein, low-density lipoprotein,</span></span></span><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"> </span></span></span></strong><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">triglyceride</span></span><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif">, and </span></span></span><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">C-reactive protein <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="font-family:&quot;Cambria&quot;,serif">serum levels (p>0.05), but it improved the quality of sleep. Omega-3 supplementation (1000 mg per day) decreased </span></span></span></span><span lang="EN" style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif">triglyceride</span></span> <span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif">and low-density lipoprotein levels, although these reductions were not significant. Additionally, omega-3 treatment significantly improved the quality of life in kidney disease and the quality of sleep in patients undergoing hemodialysis (p<0.05). The<strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"> </span></span></span></strong>coadministration of L-carnitine with omega-3 did not show superior effects compared to omega-3 alone in the evaluated parameters</span></span><span style="font-family:&quot;Cambria&quot;,serif">.<span style="background:white"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:none"><span style="font-family:Calibri,sans-serif"><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"><span style="color:#44546a">Conclusion:</span></span></span></span></strong><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"> </span></span></span></strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif">Omega-3 supplementation, both alone and in combination with L-carnitine, improves the quality of sleep and life in hemodialysis patients.</span></span></span><strong><span style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="font-family:&quot;Cambria&quot;,serif"> </span></span></span></strong><span style="font-size:10.0pt"><span style="font-family:&quot;Cambria&quot;,serif"></span></span></span></span></span></span><br> &nbsp; L-Carnitine,Omega-3 Fatty Acids,Quality of Life,Hemodialysis, 47 55 http://jccs.yums.ac.ir/browse.php?a_code=A-10-330-1&slc_lang=en&sid=1 D. Gholami 10031947532846005382 10031947532846005382 No Department of Nephrology, Faculty of Medical School, Yasuj University of Medical Sciences, Yasuj, Iran R. Abbasi Larki 10031947532846005383 10031947532846005383 No Department of Nephrology, Faculty of Medical School, Yasuj University of Medical Sciences, Yasuj, Iran L. Manzuri 10031947532846005384 10031947532846005384 No Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran T. Taheri 10031947532846005385 10031947532846005385 No Department of Medical-Surgical Nursing, Faculty of Nursing, Yasuj University of Medical Science, Yasuj, Iran A. Asfaram 10031947532846005386 10031947532846005386 No Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran H. Sadeghi Mansourkhani 10031947532846005387 10031947532846005387 Yes Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran A. Dehghan 10031947532846005388 10031947532846005388 No Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran