Journal of Clinical Care and Skills

en Evaluation of Low-Level Laser Therapy (LLLT) on Skin Wound Healing and Inflammatory Biomarkers: A Clinical and Biophysical Study Mental Health Mental Health توصيفی و نظرسنجی Descriptive Study Abstract Background: The process of healing wounds on the skin consists of various biological phenomena such as hemostasis, inflammation, proliferation, and remodeling. Nevertheless, the difficulty in healing wounds due to many factors has been the most challenging question in the clinic since persistent inflammation and the inability to regenerate tissues pose a threat to infection, make treatment lengthy, and decrease life quality. Low-Level Laser Therapy (LLLT), also referred to as photobiomodulation, has emerged as a non-invasive procedure with the potential for enhancing tissue healing and regulating inflammation. This study investigated the impact of Low-Level Laser Therapy on the healing of wounds on the skin as well as the inflammatory biomarkers related to this process through both clinical and biophysical analysis. Materials & Methods: In this group of 360 patients with either a superficial or partial thickness skin wound, a randomized clinical trial was done. The selection of the study participants resulted in 180 patients being treated for the clinical condition, while 180 received standard care alone. For 4 weeks, participants were treated with a 660-nm diode laser (100 mW, 4 J/cm²) 3 times a week. The following clinical parameters were evaluated: Percentage of wound closure, pain intensity, rate of complete healing, patient satisfaction, and the number of adverse events. The following parameters were studied in the physical assessments: Local skin temperature and tissue perfusion. Biochemical markers of inflammation like CRP, TNF-alpha, and IL-6 levels were measured before and after treatment to help assess the effectiveness of the treatment given. The significance of the study results was assessed using SPSS statistics (p<0.05). Findings: Individuals treated with LLLT had significantly better wound closure, faster healing of the affected tissue, and better recovery from the disease compared to the group with no treatment. It was also noted that the levels of TNF-α, IL-6, and CRP tended to decrease considerably after the use of LLLT, demonstrating decreased inflammation. Pain level was significantly lower, and the healing and patient satisfaction rates were higher after LLLT treatment. Conclusion: Low-Level Laser Therapy remarkably improved the healing process of wounds and decreased inflammation markers in combination with conventional wound care. A combination of results from laboratory, clinical, and biophysical studies and observations supports the therapeutic role of photobiomodulation in tissue regeneration and the management of inflammation. Further large multicentric studies are suggested with a longer follow-up period to determine the efficacy of the treatment protocols and verify the results. Photobiomodulation, low-level laser therapy, psoriasis, skin barrier, transepidermal water loss, erythema, clinical trial. 1001 1008 http://jccs.yums.ac.ir/browse.php?a_code=A-10-434-1&slc_lang=en&sid=1 B.G. Yousif bushraghali2016@gmail.com 10031947532846006733 10031947532846006733 Yes S.A. Jassim 10031947532846006734 10031947532846006734 No