IMEMR
EMRO
Volume 6, Issue 4 (2025)
J Clinic Care Skill 2025, 6(4): 1001-1011 |
Back to browse issues page
Article Type:
Subject:
History
Received: 2025/09/19 | Accepted: 2025/10/19 | Published: 2025/10/18
Received: 2025/09/19 | Accepted: 2025/10/19 | Published: 2025/10/18
How to cite this article
Rad F, Hadinia A, Masoudifar S. Red Blood Cell Alloimmunization in Thalassemia Patients: A cross-sectional study from the South-West of Iran. J Clinic Care Skill 2025; 6 (4) :1001-1011
URL: http://jccs.yums.ac.ir/article-1-428-en.html
URL: http://jccs.yums.ac.ir/article-1-428-en.html
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rights and permissions
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Abstract (59 Views)
Aims: Despite numerous studies on the prevalence of alloimmunization, its exact rate remained uncertain in many populations. In light of the Iranian Blood Transfusion Organization’s recent national program to reduce alloantibody formation, this study investigated the prevalence of alloimmunization among thalassemia patients in Kohgiluyeh and Boyer-Ahmad Province, Iran, and explored associated factors such as donor-recipient antigen homogeneity and early transfusion initiation.
Methods: A descriptive cross-sectional study was conducted on 134 beta-thalassemia major patients registered at Shahid Beheshti Hospital, Yasuj, Iran. Antibody screening was performed using both the standard tube method and the gel method in the immunohematology laboratory of Yasuj University of Medical Sciences.
Findings: Out of 134 cases, 73 (54.48%) were female and 61 (45.52%) were male, with a mean age of 19.51 ± 8.5 years. A high donor–recipient antigen homogeneity is suggested by the fact that 132 (98.5%) patients were native to Yasuj. All patients received ABO and Rh (D)-matched, leukodepleted blood transfusions at intervals ranging from 14 to 60 days (mean: 22.7 ± 6.3 days); 65.7% were splenectomized. Alloantibodies were detected in two patients (1.49% prevalence; one with anti-K and one with anti-C), both of whom had undergone splenectomy. No autoantibodies or positive direct antiglobulin test results were observed.
Conclusions: The low incidence of alloimmunization in Kohgiluyeh and Boyer-Ahmad Province may reflect high donor–recipient antigen homogeneity and the early initiation of blood transfusions. Future studies with larger cohorts and multivariate analyses are recommended to further elucidate the risk factors of alloimmunization.
Methods: A descriptive cross-sectional study was conducted on 134 beta-thalassemia major patients registered at Shahid Beheshti Hospital, Yasuj, Iran. Antibody screening was performed using both the standard tube method and the gel method in the immunohematology laboratory of Yasuj University of Medical Sciences.
Findings: Out of 134 cases, 73 (54.48%) were female and 61 (45.52%) were male, with a mean age of 19.51 ± 8.5 years. A high donor–recipient antigen homogeneity is suggested by the fact that 132 (98.5%) patients were native to Yasuj. All patients received ABO and Rh (D)-matched, leukodepleted blood transfusions at intervals ranging from 14 to 60 days (mean: 22.7 ± 6.3 days); 65.7% were splenectomized. Alloantibodies were detected in two patients (1.49% prevalence; one with anti-K and one with anti-C), both of whom had undergone splenectomy. No autoantibodies or positive direct antiglobulin test results were observed.
Conclusions: The low incidence of alloimmunization in Kohgiluyeh and Boyer-Ahmad Province may reflect high donor–recipient antigen homogeneity and the early initiation of blood transfusions. Future studies with larger cohorts and multivariate analyses are recommended to further elucidate the risk factors of alloimmunization.