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A review of laboratory findings of patients with Covid virus infection 19
Z. Daneshyar *1, N. Rahimi1
1- Clinical Research Development Unit, Imamsajad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract:   (23 Views)
In late December 2019, an unidentified case of pneumonia was reported in Wuhan City, Hubei Province, China, which the World Health Organization (WHO) named the virus COVID-19 and the International Committee for the Classification of Viruses (ICTV) SARS-CoV-2. The virus, which can enter target cells in the upper respiratory tract, leads to the clinical picture of acute respiratory distress syndrome in 4% of cases and has had a major impact in clinical microbiology laboratories. This article covers the current challenges in the laboratory diagnosis of infections caused by acute coronavirus 2 (SARS-CoV-2).
Transcriptional methods (RT-PCR) and molecular testing to select the cause of SARS-CoV-2 infection is the method of choice and antibody-based techniques are introduced as complementary tools. Collecting the right respiratory tract sample at the right time from the right anatomical location is essential for the rapid and molecular diagnosis of COVID-19.
 The clinical spectrum of 2-CoV-SARS infection is wide, including asymptomatic infection, relatively mild upper respiratory tract disease, and finally severe viral pneumonia with respiratory failure and even death. The incidence of lymphopenia, thrombocytopenia and coagulation disorders are among the cases that occur in severe cases of the disease and are associated with poor prognosis. Impaired coagulation and elevated Dimer-D levels in severe cases suggest anticoagulant therapy.
In severe cases, laboratory tests show changes in the immune system with overstimulation of the cytokine storm. In addition, biomarkers of specific organs indicate heart, kidney, and liver dysfunction in many patients. In this article, the use of laboratory biomarkers with respect to their use for diagnosis, disease progression and risk assessment is discussed.
Keywords: SARS-CoV-2, PCR, hematologic parameters
Type of Study: Research | Subject: Special
Received: 2021/06/7 | Accepted: 2021/09/4 | Published: 2021/09/12
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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مجله مهارت‌ها و مراقبت‌های بالینی Journal of Clinical Care and Skills

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