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66.92
Volume 3, Issue 2 (2022)                   J Clinic Care Skill 2022, 3(2): 67-71 | Back to browse issues page
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Masnavi E, Hosseini M, Aramesh S, Hassanzadeh S. Relationship between Vitamin D and Preeclampsia in Pregnant Women: A Comparative Descriptive Study. J Clinic Care Skill 2022; 3 (2) :67-71
URL: http://jccs.yums.ac.ir/article-1-135-en.html
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1- Department of Obstetrics and Gynecology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- Student Research Committee, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3- Department of Internal Medicine, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
* Corresponding Author Address: Yasuj University of Medical Sciences, Yasuj, Iran. (Sajad.hassanzadeh@gmail.com)
Abstract   (1838 Views)
Aims: Pregnancy poisoning or preeclampsia is a serious and specific disorder of pregnancy that affects 8% of the pregnant women. Similar studies conducted in this regard showed disagreement about the relationship between vitamin D deficiency and preeclampsia. Hence, the present study was conducted to evaluate the serum level of vitamin D in preeclampsia patients hospitalized in the maternity ward compared to healthy pregnant women.
Instruments & Methods: This descriptive comparative study was conducted on 180 pregnant women with a severe preeclampsia below the gestational age of 33 weeks and 200 non-preeclampsia pregnant women in Yasuj City from 2017 to 2019. Blood samples were taken from all subjects to measure vitamin D levels. The levels of 25-hydroxy vitamin D were measured in the laboratory using the ELISA method. Data were analyzed using SPSS 20 software.
Findings: There was no significant difference between the preeclampsia group and healthy pregnant women in terms of mean levels of vitamin D (p=0.49). Preeclamptic women with normal level of vitamin D and vitamin D deficiency showed no significant differences in the mean of uric acid, systolic blood pressure, diastolic blood pressure, and the number of previous pregnancies (p>0.05).
Conclusion: There is no relationship between serum vitamin D3 levels and hypertensive conditions of pregnancy such as preeclampsia in pregnant women. Also, vitamin D3 levels are insufficient in both groups.
 
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References
1. Eiland E, Nzerue C, Faulkner M. Preeclampsia 2012. J Pregnancy. 2012;2012:586578. [DOI:10.1155/2012/586578] [PMID] [PMCID]
2. MacKay AP, Berg CJ, Atrash HK. Pregnancy-related mortality from preeclampsia and eclampsia. Obstet Gynecol. 2001;97(4):533-8. https://doi.org/10.1097/00006250-200104000-00011 [DOI:10.1016/S0029-7844(00)01223-0]
3. Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: A systematic review. Lancet. 2006;367(9516):1066-74. [DOI:10.1016/S0140-6736(06)68397-9]
4. Azemikhah A, Amirkhani MA, Jalilvand P, Afshar NE, Radpooyan L, Changizi N. National maternal mortality
5. surveillance system in Iran. Iran J Pub Health. 2009;38(Suppl 1):90-2.
6. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AJ, Consortium ViP-eT. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): Randomised placebo-controlled trial. Lancet. 2006;367(9517):1145-54. [DOI:10.1016/S0140-6736(06)68433-X]
7. Gibbs RS, Karlan BY, Haney AF, Nygaard IE, editors. Danforth's obstetrics and gynecology. 10th Edition. Philadelphia: Pennsylvania; 2008.
8. Fiscaletti M, Stewart P, Munns C. The importance of vitamin D in maternal and child health: a global perspective. Public Health Rev. 2017;38:19. [DOI:10.1186/s40985-017-0066-3] [PMID] [PMCID]
9. Rayman MP, Bode P, Redman CW. Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom. Am J Obstet Gynecol. 2003;189(5):1343-9. [DOI:10.1067/S0002-9378(03)00723-3]
10. Hypponen E. Vitamin D for the prevention of preeclampsia? A hypothesis. Nutr Rev. 2005;63(7):225-32. https://doi.org/10.1111/j.1753-4887.2005.tb00378.x [DOI:10.1301/nr.2005.jul.225-232]
11. Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Med Hypotheses. 2010;74(1):71-5. [DOI:10.1016/j.mehy.2009.07.054] [PMID]
12. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007;92(9):3517-22. [DOI:10.1210/jc.2007-0718] [PMID] [PMCID]
13. Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre‐eclampsia. Int J Obstet Gynaecol. 2010;117(13):1593-8. [DOI:10.1111/j.1471-0528.2010.02742.x] [PMID]
14. Maghbooli Z, Hossein‐Nezhad A, Karimi F, Shafaei AR, Larijani B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev. 2008;24(1):27-32. [DOI:10.1002/dmrr.737] [PMID]
15. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol. 2010;203(4):366.e1-6.
16. Burris HH, Rifas-Shiman SL, Huh SY, Kleinman K, Litonjua AA, Oken E, et al. Vitamin D status and hypertensive disorders in pregnancy. Ann Epidemiol. 2014;24(5):399-403.e1. [DOI:10.1016/j.annepidem.2014.02.001] [PMID] [PMCID]
17. Yu C, Ertl R, Skyfta E, Akolekar R, Nicolaides K. Maternal serum vitamin D levels at 11-13 weeks of gestation in preeclampsia. J Hum Hypertens. 2013;27(2):115-8. [DOI:10.1038/jhh.2012.1] [PMID]
18. Ertl R, Yu C KH, Samaha R, Akolekar R, Nicolaides KH. Maternal serum vitamin D at 11-13 weeks in pregnancies delivering small for gestational age neonates. Fetal Diagn Ther. 2012;31(2):103-8. [DOI:10.1159/000333810] [PMID]
19. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double‐blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26(10):2341-57. [DOI:10.1002/jbmr.463] [PMID] [PMCID]
20. Schneuer FJ, Roberts CL, Guilbert C, Simpson JM, Algert CS, Khambalia AZ, et al. Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population. Am J Clin Nutr. 2014;99(2):287-95. [DOI:10.3945/ajcn.113.065672] [PMID]
21. Morley R, Carlin J, Pasco J, Wark J, Ponsonby A. Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype. Eur J Clin Nutr. 2009;63(6):802-4. [DOI:10.1038/ejcn.2008.55] [PMID]
22. Ghomian N, Lotfalizade M, Movahedian A. Comparative study of serum level of vitamin D in pregnant women with preeclampsia and normal pregnant women. Iran J Obstet Gynecol Infertil. 2015;18(140):1-6.
23. Zhao X, Fang R, Yu R, Chen D, Zhao J, Xiao J. Maternal vitamin D status in the late second trimester and the risk of severe preeclampsia in southeastern China. Nutrients. 2017;9(2):138. [DOI:10.3390/nu9020138] [PMID] [PMCID]
24. Mohammadian S, Salehi NM, Mohammadian Y. Comparison of Serum Levels of Vitamin D in Nulliparous Women with Severe Preeclampsia with Healthy Pregnant Woman. Qom Univ Med Sci J. 2019;13(8):26-32. [DOI:10.29252/qums.13.8.26]
25. Karpa M, Thakur S, Singh K, Sharma J, Chaudhary H. To compare serum Vitamin D status in pre-eclamptic and non-preeclamptic pregnant women in labour: A tertiary care centre study of Northern India. Clin J Obstet Gynecol. 2022;5(1):013-8. [DOI:10.29328/journal.cjog.1001100]
26. Purswani JM, Gala P, Dwarkanath P, Larkin HM, Kurpad A, Mehta S. The role of vitamin D in pre-eclampsia: A systematic review. BMC Pregnancy Childbirth. 2017;17(1):231. [DOI:10.1186/s12884-017-1408-3] [PMID] [PMCID]
27. Akbari S, Khodadadi B, Ahmadi SA, Abbaszadeh S, Shahsavar F. Association of vitamin D level and vitamin D deficiency with risk of preeclampsia: A systematic review and updated meta-analysis. Taiwan J Obstet Gynecol. 2018;57(2):241-7. [DOI:10.1016/j.tjog.2018.02.013] [PMID]
28. Haugen M, Brantsæter AL, Trogstad L, Alexander J, Roth C, Magnus P, et al. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology. 2009;20(5):720-6. [DOI:10.1097/EDE.0b013e3181a70f08] [PMID]
29. Tabesh M, Salehi-Abargouei A, Tabesh M, Esmaillzadeh A. Maternal vitamin D status and risk of pre-eclampsia: A systematic review and meta-analysis. J Clin Endocrinol Metab. 2013;98(8):3165-73. [DOI:10.1210/jc.2013-1257] [PMID]
30. Wei S-Q, Qi H-P, Luo Z-C, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2013;26(9):889-99. [DOI:10.3109/14767058.2013.765849] [PMID]
31. Bodnar LM, Catov JM, Roberts JM. Racial/ethnic differences in the monthly variation of preeclampsia incidence. Am J Obstet Gynecol. 2007;196(4):324.e1-5. [DOI:10.1016/j.ajog.2006.11.028] [PMID]
32. Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O'Beirne M, et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of observational studies. BMJ. 2013;346:f1169. [DOI:10.1136/bmj.f1169] [PMID]
33. Thorne‐Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: A systematic review and meta‐analysis. Paediatr Perinat Epidemiol. 2012;26(Suppl 1):36-54. [DOI:10.1111/j.1365-3016.2012.01284.x] [PMID] [PMCID]