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:: Volume 3, Issue 4 (2022) ::
J Clinic Care Skill 2022, 3(4): 191-196 Back to browse issues page
Comparing the Effect of Different Doses of Vitamin D Supplementation During Pregnancy on Prevention of Adverse Pregnancy Outcomes; a Randomized Clinical Trial
R. Vanda1 , S. Hassanzadeh2 , E. Masnavi * 3
1- Department of Obstetrics and Gynecology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- Department of Internal Medicine, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3- Department of Obstetrics and Gynecology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran , Elahe.masnavi@yahoo.com
Abstract:   (976 Views)
Aims: Repeated pregnancy loss (RPL) is commonly considered as ≥3 fetal losses previously 20 weeks of gestation. Vitamin D has an important role on immune inflection at the maternal‑fetal part. Though, vitamin D can be utilized as a useful approach to treat patients with repeated pregnancy loss. There was lack of consensus on prescribing Vitamin D during pregnancy to prevent pregnancy complications. However, the present study was conducted to compare the effect of low and high dose of Vitamin D on to prevent pregnancy complications.  
Materials & Methods: We conducted a single-blinded, randomized controlled trial in Yasuj, Iran, to assess the influence of different doses of vitamin D supplement through pregnancy in women on pregnancy and birth outcomes (preterm births and stillbirths, pre-eclampsia, gestational diabetes and low birth weight,
Findings: Patients (n=150) in their first trimester were enrolled and randomized to two groups of vitamin D supplementation; 500IU/day (group A; n=70) and 2000IU/day (group B; n=70). 131 patients completed the intervention. Maternal vitamin D supplementation  2000IU/day had a positive effect only on gestational diabetes mellitus, spontaneous miscarriage and preeclampsia and preterm births but there was no statistically significant difference between two groups (p>0.05).
Conclusion: Increasing dose from 500 units to 2000 units per day does not increase the effectiveness of vitamin D to decrease pregnancy complications. Vitamin D supplementation (500 IU/day) appeared sufficient to reduce the risk of pregnancy complications as well as the higher dose.
 
Keywords: Vitamin D, Spontaneous Miscarriage, Neonate Birth, Preterm Labor
Full-Text [PDF 3539 kb]   (341 Downloads)    
Type of Study: Research | Subject: Special
Received: 2022/10/29 | Accepted: 2022/12/1 | Published: 2022/12/10
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Vanda R, Hassanzadeh S, Masnavi E. Comparing the Effect of Different Doses of Vitamin D Supplementation During Pregnancy on Prevention of Adverse Pregnancy Outcomes; a Randomized Clinical Trial. J Clinic Care Skill 2022; 3 (4) :191-196
URL: http://jccs.yums.ac.ir/article-1-159-en.html


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Volume 3, Issue 4 (2022) Back to browse issues page
مجله مهارت‌ها و مراقبت‌های بالینی Journal of Clinical Care and Skills

 
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