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Volume 5, Issue 1 (2024)                   J Clinic Care Skill 2024, 5(1): 1001-1006 | Back to browse issues page

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Nouripour-Sisakht S, Diba A, Razmjoue D, Zanganeh P, Salahi M, Gharaghani M. Anticandida activities of Salvia macrosiphon, in a single form and comparison with fluconazole. J Clinic Care Skill 2024; 5 (1) :1001-1006
URL: http://jccs.yums.ac.ir/article-1-217-en.html
1- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract:   (226 Views)
Background: Candidiasis is the most opportunistic infection with a high rate of recurrent infection. The Lamiaceae family is one of the important herbal drugs and compromised many species. This study aimed to investigate the chemical composition of essential oil from leaves of Salvia macrosiphon with its antifungal activity of it compared with fluconazole.
Materials and methods: Salvia macrosiphon leaves, a native plant of Kogiluyeh and boyerahmad states, were collected from Zagros heights, and used in this study. Then, the essential oil of this plant was tested for antibacterial and antifungal properties and compared with fluconazole.  The chemical composition of the essential oil was analyzed by GC/MS (Gas Chromatography Mass Spectrometry) and the antifungal activity of the plant essential oil was compared with fluconazole.
Findings: The results of GC-MS analysis proved the presence of at least 29 compounds in the essential oil of S. macrosiphon. Amon these constitute, butyl benzoate (49.16%), n-hexyl benzoate (7%), and isopatolenol (4.83%) were the main compound. The minimum inhibitory concentration (MIC) of the essential oil (µl/ml) of S. macrosiphon and fluconazole (μg/ml) were 0.44 and 0.7 for Candida albicans, 0.056 and 0.7 for C. glabrata, and 0.1 and 0.088 for C.parapsilosis, respectively.
Conclusion: Based on the results and other studies, the essential oil of S. macrosiphon can be used as a new drug or a source of antifungal compounds alone or as a supplement with industrial drugs. Also, our findings in this study showed stronger antifungal activity of plant essential oil compared to fluconazole
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Article Type: Original Research | Subject: General
Received: 2023/11/2 | Accepted: 2024/01/10 | Published: 2024/02/21

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