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Volume 6, Issue 2 (2025)
J Clinic Care Skill 2025, 6(2): 59-64 |
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Ethics code: IR.YUMS.REC.1402.154
History
Received: 2025/03/20 | Accepted: 2025/05/8 | Published: 2025/05/12
Received: 2025/03/20 | Accepted: 2025/05/8 | Published: 2025/05/12
How to cite this article
Hashemimohammadabad Z, Hashemimohammadabad M, Yazdanpanah I, Razmjoue D, Karimi F, Hashemimohammadabad N. Effect of Melissa Officinalis on Depression in affected Individuals. J Clinic Care Skill 2025; 6 (2) :59-64
URL: http://jccs.yums.ac.ir/article-1-397-en.html
URL: http://jccs.yums.ac.ir/article-1-397-en.html
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Authors
Z. Hashemimohammadabad1, M. Hashemimohammadabad2, I. Yazdanpanah1, D. Razmjoue3, F. Karimi4, N. Hashemimohammadabad *5
1- College of Medicine, Zhejiang University of Medical Sciences, Zhejiang, China
2- College of Medicine, Zhengzhou University of Medical Sciences, Zhengzhou, China
3- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4- College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
5- Department of Psychiatry, College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- College of Medicine, Zhengzhou University of Medical Sciences, Zhengzhou, China
3- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4- College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
5- Department of Psychiatry, College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract (207 Views)
Aims: The aim of this study was to determine the effectiveness of the hydrolyzed extract from Melissa officinalis in patients with depression who are taking escitalopram.
Materials & Methods: This quasi-experimental using pre-test and post-test phases, assessed 78 patients in 2023. The participants were divided into two groups of 39. In the control group, escitalopram (10mg daily, single tablet) was prescribed for 30 days, while in the intervention group, escitalopram (10mg daily, single tablet) and Melissa officinalis hydrochloride capsules (500mg daily, single tablet) were prescribed for 30 days. Depression was measured using the Hamilton Depression Rating Scale and the Beck Depression Inventory. For data analysis, chi-square tests, paired t-tests, and independent t-tests with a significance level of 0.05 were employed, using SPSS version 26.
Findings: Regarding demographic factors, there was no statistically significant difference in treatment rates between the intervention and control groups. There was no significant difference between the two groups in the severity of depression, as measured by the Beck and Hamilton scales in the pre-test (p=0.533, p=0.570). The severity of depression decreased significantly (p<0.001) in both groups in the post-test, but the severity of depression on both scales decreased significantly (p<0.001) in the intervention group after the intervention.
Conclusion: The extract of Melissa officinalis is effective in reducing symptoms of depression when used in combination with the medication escitalopram.
Materials & Methods: This quasi-experimental using pre-test and post-test phases, assessed 78 patients in 2023. The participants were divided into two groups of 39. In the control group, escitalopram (10mg daily, single tablet) was prescribed for 30 days, while in the intervention group, escitalopram (10mg daily, single tablet) and Melissa officinalis hydrochloride capsules (500mg daily, single tablet) were prescribed for 30 days. Depression was measured using the Hamilton Depression Rating Scale and the Beck Depression Inventory. For data analysis, chi-square tests, paired t-tests, and independent t-tests with a significance level of 0.05 were employed, using SPSS version 26.
Findings: Regarding demographic factors, there was no statistically significant difference in treatment rates between the intervention and control groups. There was no significant difference between the two groups in the severity of depression, as measured by the Beck and Hamilton scales in the pre-test (p=0.533, p=0.570). The severity of depression decreased significantly (p<0.001) in both groups in the post-test, but the severity of depression on both scales decreased significantly (p<0.001) in the intervention group after the intervention.
Conclusion: The extract of Melissa officinalis is effective in reducing symptoms of depression when used in combination with the medication escitalopram.
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