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Volume 6, Issue 2 (2025)
J Clinic Care Skill 2025, 6(2): 89-103 |
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Ethics code: IR.YUMS.REC.1400.119
History
Received: 2025/05/15 | Accepted: 2025/06/28 | Published: 2025/07/1
Received: 2025/05/15 | Accepted: 2025/06/28 | Published: 2025/07/1
How to cite this article
Fazeli M, Malekzadeh M, Bayatmanesh H, Neysarian P, Arefkhah N, Sedaghattalab M. Effects of Interferon Beta-1 and Dexamethasone on the Treatment of Hospitalized COVID-19 Patients. J Clinic Care Skill 2025; 6 (2) :89-103
URL: http://jccs.yums.ac.ir/article-1-403-en.html
URL: http://jccs.yums.ac.ir/article-1-403-en.html
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Authors
M.A. Fazeli1, M. Malekzadeh2, H. Bayatmanesh3, P. Neysarian4, N. Arefkhah1, M. Sedaghattalab *5
1- Department of Infectious Disease, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- Social Determinant of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3- “Imam Sajad Hospital” and “Department of Nursing, Faculty of Nursing & Midwifery”, Yasuj University of Medical Sciences, Yasuj, Iran
4- “Shahid Jalil Hospital” and “Department of Midwifery, Faculty of Nursing & Midwifery”, Yasuj University of Medical Sciences, Yasuj, Iran
5- Department of Internal Medicine, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- Social Determinant of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3- “Imam Sajad Hospital” and “Department of Nursing, Faculty of Nursing & Midwifery”, Yasuj University of Medical Sciences, Yasuj, Iran
4- “Shahid Jalil Hospital” and “Department of Midwifery, Faculty of Nursing & Midwifery”, Yasuj University of Medical Sciences, Yasuj, Iran
5- Department of Internal Medicine, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract (311 Views)
Aims: Despite the urgent need to treat the COVID-19 pandemic, no effective treatment has been identified to date. The present study aimed to compare the effects of interferon Beta-1 and dexamethasone on the treatment of hospitalized COVID-19 patients.
Materials & Methods: This phase 2, open-label, randomized trial examined adult patients who were admitted to hospitals in Yasuj, Iran, from October 2021 to May 2022 due to COVID-19. Patients were randomly assigned to intervention group 1 (88 patients), which included remdesivir, interferon beta-1, and dexamethasone, and intervention group 2 (88 patients), which included remdesivir and dexamethasone, in a ratio of 1:1. The mean arterial blood O2 saturation and length of hospitalization for both groups were compared.
Findings: The two groups did not show a significant difference in terms of demographic characteristics and disease-related parameters at baseline (p>0.05). The mean O2 saturation at the time of discharge for group 1 (90.14±10.72) and group 2 (92.54±3.19) demonstrated a significant difference (p<0.05). The mean length of hospitalization for group 1 (7.02±2.56) and group 2 (5.73±2.04) was significantly different (p<0.01). There was a significant difference between the number of deaths in group 1 (7 patients) and group 2 (0 patients; p<0.01).
Conclusion: The administration of remdesivir and dexamethasone, compared to remdesivir, dexamethasone, and interferon, results in a decreased length of hospitalization, reduced mortality, and improved O2 saturation.
Materials & Methods: This phase 2, open-label, randomized trial examined adult patients who were admitted to hospitals in Yasuj, Iran, from October 2021 to May 2022 due to COVID-19. Patients were randomly assigned to intervention group 1 (88 patients), which included remdesivir, interferon beta-1, and dexamethasone, and intervention group 2 (88 patients), which included remdesivir and dexamethasone, in a ratio of 1:1. The mean arterial blood O2 saturation and length of hospitalization for both groups were compared.
Findings: The two groups did not show a significant difference in terms of demographic characteristics and disease-related parameters at baseline (p>0.05). The mean O2 saturation at the time of discharge for group 1 (90.14±10.72) and group 2 (92.54±3.19) demonstrated a significant difference (p<0.05). The mean length of hospitalization for group 1 (7.02±2.56) and group 2 (5.73±2.04) was significantly different (p<0.01). There was a significant difference between the number of deaths in group 1 (7 patients) and group 2 (0 patients; p<0.01).
Conclusion: The administration of remdesivir and dexamethasone, compared to remdesivir, dexamethasone, and interferon, results in a decreased length of hospitalization, reduced mortality, and improved O2 saturation.
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