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Volume 6, Issue 3 (2025)
J Clinic Care Skill 2025, 6(3): 113-119 |
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Ethics code: IR.SBMU.NNFTRI.REC.1399.067
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Received: 2025/06/12 | Accepted: 2025/07/19 | Published: 2025/08/15
Received: 2025/06/12 | Accepted: 2025/07/19 | Published: 2025/08/15
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Haghshenosabet F, Eslamian G, Kazemi S, Rashidkhani B. Association Between Ultra-Processed Foods Before Pregnancy and Hyperemesis Gravidarum. J Clinic Care Skill 2025; 6 (3) :113-119
URL: http://jccs.yums.ac.ir/article-1-416-en.html
URL: http://jccs.yums.ac.ir/article-1-416-en.html
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1- “Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology” and “National Nutrition and Food Technology Research Institute”, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- “Department of Obstetrics and Gynecology, Faculty of Medicine” and “Preventative Gynecology Research Center”, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- “Department of Community Nutrition, Faculty of Nutrition and Food Technology” and “National Nutrition and Food Technology Research Institute”, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- “Department of Obstetrics and Gynecology, Faculty of Medicine” and “Preventative Gynecology Research Center”, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- “Department of Community Nutrition, Faculty of Nutrition and Food Technology” and “National Nutrition and Food Technology Research Institute”, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract (832 Views)
Aims: Hyperemesis gravidarum is a multifactorial pregnancy disorder characterized by severe nausea and vomiting, often necessitating hospitalization. While its etiology remains incompletely understood, dietary factors may play a significant role. This study investigated the association between pre-pregnancy consumption of ultra-processed foods and the incidence of hyperemesis gravidarum.
Instrument & Methods: This hospital-based case-control study was conducted in Tehran, Iran, from April 2020 to June 2021, involving 45 newly diagnosed hyperemesis gravidarum cases and 126 controls. Hyperemesis gravidarum diagnosis followed the criteria set by the American College of Obstetrics and Gynecology. Pre-pregnancy ultra-processed food intake was assessed using a validated Semi-Quantitative Food Frequency Questionnaire, with foods classified according to the NOVA system. Multivariable logistic regression analyses, adjusted for potential confounders, were employed to evaluate the association between ultra-processed food consumption and hyperemesis gravidarum risk.
Findings: After adjusting for covariates, significant inverse associations were observed between higher ultra-processed food intake and hyperemesis gravidarum risk. The multivariable-adjusted odds ratios for the highest versus lowest tertile of ultra-processed food consumption were as follows: Total ultra-processed foods (odds ratio: 0.31; 95% CI: 0.19-0.48; p-value=0.002), dairy beverages (odds ratio: 0.18; 95% CI: 0.09-0.52; p-value=0.048), and processed meats/fast foods (odds ratio: 0.13; 95% CI: 0.06-0.71; p-value=0.015).
Conclusion: Lower pre-pregnancy ultra-processed food consumption is associated with reduced odds of developing hyperemesis gravidarum.
Instrument & Methods: This hospital-based case-control study was conducted in Tehran, Iran, from April 2020 to June 2021, involving 45 newly diagnosed hyperemesis gravidarum cases and 126 controls. Hyperemesis gravidarum diagnosis followed the criteria set by the American College of Obstetrics and Gynecology. Pre-pregnancy ultra-processed food intake was assessed using a validated Semi-Quantitative Food Frequency Questionnaire, with foods classified according to the NOVA system. Multivariable logistic regression analyses, adjusted for potential confounders, were employed to evaluate the association between ultra-processed food consumption and hyperemesis gravidarum risk.
Findings: After adjusting for covariates, significant inverse associations were observed between higher ultra-processed food intake and hyperemesis gravidarum risk. The multivariable-adjusted odds ratios for the highest versus lowest tertile of ultra-processed food consumption were as follows: Total ultra-processed foods (odds ratio: 0.31; 95% CI: 0.19-0.48; p-value=0.002), dairy beverages (odds ratio: 0.18; 95% CI: 0.09-0.52; p-value=0.048), and processed meats/fast foods (odds ratio: 0.13; 95% CI: 0.06-0.71; p-value=0.015).
Conclusion: Lower pre-pregnancy ultra-processed food consumption is associated with reduced odds of developing hyperemesis gravidarum.
Keywords:
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