Background: Loneliness and social isolation are established independent predictors of adverse cardiovascular outcomes. Despite robust evidence linking these psychosocial stressors to increased mortality and morbidity, they remain under-addressed in routine nursing care pathways. This systematic review synthesized the available evidence on the nature and efficacy of nursing-led interventions designed to mitigate these risks in cardiovascular patients.

Methods: Following PRISMA 2020 guidelines, a systematic search was conducted across PubMed/MEDLINE, Scopus, Web of Science, CINAHL, and PsycINFO for studies published between January 2000 and December 2024. Methodological quality was rigorously assessed using the Cochrane Risk of Bias (RoB 2.0) and Newcastle-Ottawa Scale.

Results: Fifty-seven studies met the inclusion criteria. The review identified three primary modalities of nursing-led support: structured cognitive-behavioral approaches, tele-health monitoring, and community-based social prescribing. The majority of included trials reported significant clinical improvements in patient-reported loneliness scores and social integration. Findings indicate that nursing-led interventions are most effective when integrated into long-term cardiac rehabilitation programs rather than limited to acute post-discharge phases.

Conclusion: Nursing professionals play a pivotal role in identifying and managing the psychosocial determinants of cardiac health. Routine screening for loneliness should be embedded into standard cardiovascular nursing protocols. Future research should prioritize large-scale longitudinal studies to determine the sustained impact of these nursing-led models on hard clinical endpoints, such as readmission rates and mortality.