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Volume 2, Issue 1 (2021)
J Clinic Care Skill 2021, 2(1): 29-34 |
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Received: 2019/07/30 | Accepted: 2020/06/30 | Published: 2021/01/26
Received: 2019/07/30 | Accepted: 2020/06/30 | Published: 2021/01/26
How to cite this article
Sadeghi Mansoorkhani H, Alamdari M, Hasanzadeh S, Jokar S, Panahi Kokhdan E, Malekzadeh J et al . Effect of Rosa damascene Mill. Hydroalcoholic Extract on the Treatment of Chronic Idiopathic Constipation in Adults. J Clinic Care Skill 2021; 2 (1) :29-34
URL: http://jccs.yums.ac.ir/article-1-67-en.html
URL: http://jccs.yums.ac.ir/article-1-67-en.html
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Authors
H. Sadeghi Mansoorkhani1, M. Alamdari2, S. Hasanzadeh *2, S. Jokar3, E. Panahi Kokhdan1, J. Malekzadeh4, R. Abassi5
1- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
2- Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3- Internal Medicine Department, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
4- Nutrition Department, Faculty of Health Sciences, Yasuj University of Medical Sciences, Yasuj, Iran
5- Pediatric Department, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
2- Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3- Internal Medicine Department, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
4- Nutrition Department, Faculty of Health Sciences, Yasuj University of Medical Sciences, Yasuj, Iran
5- Pediatric Department, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract (2027 Views)
Aims: Constipation is an important problem and dysfunction of the digestive system. In the traditional beliefs of different parts of the world, especially Iran, Rosa damascene Mill. has several properties, including sedative, anti-inflammatory, anti-seizure, anti-depressant, and laxative effects. This study aimed to evaluate the effect of hydroalcoholic extract of Rosa damascene Mill. in treating chronic constipation in adults.
Materials & Methods: This randomized clinical trial was performed in 2018 in Shahid Mofteh Specialized Clinic of Yasouj on 160 patients with chronic constipation referred to internal medicine and gastroenterologists. Extracted hydroalcoholic extract of Rosa damascene Mill. and lactulose syrup was used; The control group received 20cc of lactulose syrup twice a day, and the intervention group received a hydroalcoholic extract of Rosa damascene Mill. two times a day in the form of 500mg capsules twice a day for one month. Data were analyzed using SPSS 19 software and T and chi-square tests with 95% confidence interval.
Findings: During the intervention process, 16 people did not refer to the necessary follow-up, and the necessary information was collected from 144 patients with chronic constipation. Sixty-eight patients (4.2%) were male, and 76 (52.8%) were female. The mean age of patients was 43.18±13.67, and the age range was 18 to 75 years. There was no statistically significant difference between the two groups' mean age and sex under Rosa damascene Mill.'s intervention. Hydroalcoholic extract and lactulose (p<0.05). Also, there was no statistically significant difference between the variables of frequency and ease of defecation between the two groups receiving lactulose and Rosa damascene Mill. hydroalcoholic extract before and after the intervention (p<0.05).
Conclusion: Hydroalcoholic extract of Rosa damascene Mill. has a similar effect to lactulose in the treatment of chronic constipation in adults.
Materials & Methods: This randomized clinical trial was performed in 2018 in Shahid Mofteh Specialized Clinic of Yasouj on 160 patients with chronic constipation referred to internal medicine and gastroenterologists. Extracted hydroalcoholic extract of Rosa damascene Mill. and lactulose syrup was used; The control group received 20cc of lactulose syrup twice a day, and the intervention group received a hydroalcoholic extract of Rosa damascene Mill. two times a day in the form of 500mg capsules twice a day for one month. Data were analyzed using SPSS 19 software and T and chi-square tests with 95% confidence interval.
Findings: During the intervention process, 16 people did not refer to the necessary follow-up, and the necessary information was collected from 144 patients with chronic constipation. Sixty-eight patients (4.2%) were male, and 76 (52.8%) were female. The mean age of patients was 43.18±13.67, and the age range was 18 to 75 years. There was no statistically significant difference between the two groups' mean age and sex under Rosa damascene Mill.'s intervention. Hydroalcoholic extract and lactulose (p<0.05). Also, there was no statistically significant difference between the variables of frequency and ease of defecation between the two groups receiving lactulose and Rosa damascene Mill. hydroalcoholic extract before and after the intervention (p<0.05).
Conclusion: Hydroalcoholic extract of Rosa damascene Mill. has a similar effect to lactulose in the treatment of chronic constipation in adults.
Keywords:
References
1. Peppas G, Alexiou VG, Mourtzoukou E, Falagas ME. Epidemiology of constipation in Europe and Oceania: A systematic review. BMC Gastroenterol. 2008;8:5. [DOI:10.1186/1471-230X-8-5] [PMID] [PMCID]
2. Jun DW, Park HY, Lee OY, Lee HL, Yoon BC, Choi HS, et al. A population-based study on bowel habits in a Korean community: Prevalence of functional constipation and self-reported constipation. Dig Dis Sci. 2006;51(8):1471-7. [DOI:10.1007/s10620-006-9087-3] [PMID]
3. Murakami K, Sasaki S, Okubo H, Takahashi Y, Hosoi Y, Itabashi M. Dietary fiber intake, dietary glycemic index and load, and body mass index: A cross-sectional study of 3931 Japanese women aged 18-20 years. Eur J Clin Nutr. 2007;61(8):986-95. [DOI:10.1038/sj.ejcn.1602610] [PMID]
4. Khoshbaten M, Hekmatdoost A, Ghasemi H, Entezariasl M. Prevalence of gastrointestinal symptoms and signs in northwestern Tabriz, Iran. Indian J Gastroenterol. 2004;23(5):168-70.
5. Adibi P, Behzad E, Pirzadeh S, Mohseni M. Bowel habit reference values and abnormalities in young Iranian healthy adults. Dig Dis Sci. 2007;52(8):1810-3. [DOI:10.1007/s10620-006-9509-2] [PMID]
6. Epstein D. Chronic idiopathic constipation. Continu Med Educ. 2009;27(5).
7. National Collaborating Centre for Women's and Children's Health (UK). Constipation in children and young people: Diagnosis and management of idiopathic childhood constipation in primary and secondary care. London: RCOG Press; 2010.
8. Russo M, Strisciuglio C, Scarpato E, Bruzzese D, Casertano M, Staiano A. Functional chronic constipation: Rome III criteria versus Rome IV criteria. J Neurogastroenterol Motil. 2019;25(1):123-8. [DOI:10.5056/jnm18035] [PMID] [PMCID]
9. Momeni T, Shahrokhi N. Essential oils and their therapeutic actions. Tehran: University of Tehran Press; 1991. [Persian]
10. Arezoomandan R, Kazerani HR, Behnam-Rasooli M. The laxative and prokinetic effects of Rosa damascena Mill in rats. Iran J Basic Med Sci. 2011;14(1):9-16.
11. Sheikh ZA, Khan AA, Nawaz A, Zahoor A, Khan SS, Usmanghani K. Development and clinical evaluation of polyherbal laxative laxisen. RADS J Pharm Pharm Sci. 2014;2(2):63-70.
12. Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum. 2001;44(8):1201-9. [DOI:10.1007/BF02234645] [PMID]
13. Nikbakht A, Kafi M. A study on the relationships between Iranian people and Damask rose (Rosa damascena) and its therapeutic and healing properties. Acta Hortic. 2004;790:251-4. [DOI:10.17660/ActaHortic.2008.790.36]
14. Mohammadzadeh SH, Karim MH, Karbasi AR. Global value chain analysis of Damask Rose in the world and Iran. The Second International Conference on Rosa damascena. Mashhad: Ferdowsi Uiversity; 2019.
15. Amini A, Bahraminejad N, Jafari S, Kamali K. The effect of aromatherapy with rosa damascena essence on postoperative pain in inguinal hernia repair: A randomized clinical trial. Nurs Midwifery Stud. 2020;9(3):117-23. [DOI:10.4103/nms.nms_103_19]
16. Attia H, Al-Yasi H, Alamer K, Esmat F, Hassan F, Elshazly S, et al. Induced anti-oxidation efficiency and others by salt stress in Rosa damascena Miller. Scientia Horticulturae. 2020;274:109681. [DOI:10.1016/j.scienta.2020.109681]
17. Hashem Dabaghian F, Taghavi Shirazi M, Amini Behbahani F, Shojaee A. Interventions of Iranian traditional medicine for constipation during pregnancy. J Med Plant. 2015;14(53):58-68. [Persian]
18. Naftali T, Feingelernt H, Lesin Y, Rauchwarger A, Konikoff FM. Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: A controlled clinical trial. Digestion. 2008;78(4):224-8. [DOI:10.1159/000190975] [PMID]
19. Blake MR, Raker JM, Whelan K. Validity and reliability of the Bristol Stool Form Scale in healthy adults and patients with diarrhoea‐predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2016;44(7):693-703. [DOI:10.1111/apt.13746] [PMID]
20. Simren M, Palsson OS, Whitehead WE. Update on Rome IV criteria for colorectal disorders: Implications for clinical practice. Curr Gastroenterol Rep. 2017;19(4):15. [DOI:10.1007/s11894-017-0554-0] [PMID] [PMCID]
21. Varma MG, Wang JY, Berian JR, Patterson TR, McCrea GL, Hart SL. The constipation severity instrument: A validated measure. Dis Colon Rectum. 2008;51(2):162-72. [DOI:10.1007/s10350-007-9140-0] [PMID]
22. Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascena. Iran J Basic Med Sci. 2011;14(4):295.
23. Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Res. 2010;9(2):163-8.
24. Panahi Kokhdan E, Ahmadi K, Sadeghi H, Sadeghi H, Dadgary F, Danaei N, et al. Hepatoprotective effect of Stachys pilifera ethanol extract in carbon tetrachloride-induce hepatotoxicity in rats. Pharm Biol. 2017;55(1):1389-93. [DOI:10.1080/13880209.2017.1302484] [PMID] [PMCID]
25. Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27-31. [DOI:10.4103/0976-0105.177703] [PMID] [PMCID]
26. Abbaszadeh M, Kazerani HR, Kamrani A. Laxative effects of Rosa damascene Mill in dogs. J Appl Anim Res. 2010;38(1):89-92. [DOI:10.1080/09712119.2010.9707162]
27. Akram M, Riaz M, Munir N, Akhter N, Zafar S, Jabeen F, et al. Chemical constituents, experimental and clinical pharmacology of Rosa damascena: A literature review. J Pharm Pharmacol. 2020;72(2):161-74. [DOI:10.1111/jphp.13185] [PMID]
28. Tabrizi H, Mortazavi SA, Kamalinejad M. An in vitro evaluation of various Rosa damascena flower extracts as a natural antisolar agent. Int J Cosmet Sci. 2003;25(6):259-65. [DOI:10.1111/j.1467-2494.2003.00189.x] [PMID]
29. Dolati K, Rakhshandeh H, Shafei MN. Effect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs. Avicenna j Phytomed. 2013;3(3):248-53.
30. Sadraei H, Asghari G, Emami S. Effect of Rosa damascena Mill. flower extract on rat ileum. Res Pharm Sci. 2013;8(4):277-84.
31. Piche T, Dapoigny M. Comparative efficacy and safety of lactulose plus paraffin vs polyethylene glycol in functional constipation: A randomised clinical study. United Eur Gastroenterol J. 2020;8(8):923-32. [DOI:10.1177/2050640620937913] [PMID] [PMCID]
32. Lee‐Robichaud H, Thomas K, Morgan J, Nelson RL. Cochrane review: Lactulose versus polyethylene glycol for chronic constipation. Evid Based Child Health Cochrane Rev J. 2011;6(3):824-64. [DOI:10.1002/ebch.741]
33. Chung S, Cheng A, Goldman RD. Polyethylene glycol 3350 without electrolytes for the treatment of functional constipation in infants and toddlers. Can Fam Physician. 2009;55(5):481-2.
34. Maydeo A. Lactitol or lactulose in the treatment of chronic constipation: Result of a systematic. J Indian Med Assoc. 2010;108(11):789-92.
35. Hongratanaworakit T. Relaxing effect of rose oil on humans. Nat Prod Commun. 2009;4(2):291-6. [DOI:10.1177/1934578X0900400226]