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Volume 7, Issue 2 (2026)
J Clinic Care Skill 2026, 7(2): 1001-1006 |
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Ethics code: IR.YUMS.REC.1403.029
History
Received: 2026/06/23 | Accepted: 2026/07/25 | Published: 2026/04/21
Received: 2026/06/23 | Accepted: 2026/07/25 | Published: 2026/04/21
How to cite this article
Ahmadi S, Ariya A, Gorjipour N, Manzouri L. Investigating the relationship between D-dimer serum level and diabetic retinopathy in patients with type 2 diabetes. J Clinic Care Skill 2026; 7 (2) :1001-1006
URL: http://jccs.yums.ac.ir/article-1-496-en.html
URL: http://jccs.yums.ac.ir/article-1-496-en.html
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Abstract (18 Views)
Introduction: Diabetic retinopathy (DR) is a major complication of type 2 diabetes (T2D) associated with microvascular damage and potential vision loss. D-dimer, a fibrin degradation product, serves as a marker of coagulation and fibrinolysis and may play a role in the development of DR.This study aims to investigate the association between plasma D-dimer levels and the presence of diabetic retinopathy (DR) in patients with type 2 diabetes (T2D).
Materials & Methods: This cross-sectional descriptive-analytical study included 60 patients with T2D, divided into two groups: the DR group (n=30) and the non-DR group (n=30). Clinical and demographic data, including age, gender, duration of diabetes, medication use, and D-dimer levels, were collected and analyzed. Independent t-tests, Mann-Whitney tests, and univariate linear regression were employed for statistical analysis.
Findings: The mean age of patients with DR was significantly higher than that of those without DR (57.60 ± 8.97 years vs. 51.33 ± 11.01 years, P=0.019). Univariate linear regression indicated a direct and significant relationship between D-dimer levels and DR (odds ratio: 0.34; P=0.009).
Conclusions: This study demonstrated that higher D-dimer levels are significantly associated with DR in T2D patients, along with older age, longer duration of diabetes, and distinct patterns of medication use. These findings suggest that D-dimer may be a potential biomarker for identifying T2D patients at greater risk for DR.
Materials & Methods: This cross-sectional descriptive-analytical study included 60 patients with T2D, divided into two groups: the DR group (n=30) and the non-DR group (n=30). Clinical and demographic data, including age, gender, duration of diabetes, medication use, and D-dimer levels, were collected and analyzed. Independent t-tests, Mann-Whitney tests, and univariate linear regression were employed for statistical analysis.
Findings: The mean age of patients with DR was significantly higher than that of those without DR (57.60 ± 8.97 years vs. 51.33 ± 11.01 years, P=0.019). Univariate linear regression indicated a direct and significant relationship between D-dimer levels and DR (odds ratio: 0.34; P=0.009).
Conclusions: This study demonstrated that higher D-dimer levels are significantly associated with DR in T2D patients, along with older age, longer duration of diabetes, and distinct patterns of medication use. These findings suggest that D-dimer may be a potential biomarker for identifying T2D patients at greater risk for DR.
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