Volume 5, Issue 1 (2024)                   J Clinic Care Skill 2024, 5(1): 1001-1018 | Back to browse issues page

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NematiShahri F, Pouresmaeil O, Sharifi A, Mardani F, Mardaneh J. Female Genital Tuberculosis: A Systematic Review. J Clinic Care Skill 2024; 5 (1) :1001-1018
1- 1Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. ,
2- Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
3- Microbiology Laboratory, Allameh Bohlul Hospital, Gonabad University of Medical Sciences, Gonabad, Iran.
4- Department of Microbiology, School of Medicine, Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
Abstract:   (154 Views)
Aims: Female genital tuberculosis is an infrequent form of tuberculosis that often underestimated due to its low prevalence in developed countries, difficult and delayed diagnosis, and misleading clinical presentation. Therefore, the purpose of this systematic review is to describe the epidemiology, clinical presentation, diagnosis, and treatment of Female genital tuberculosis during the years 2000-2011.
Methods: This systematic review was conducted by searching the keywords such as “female genital tuberculosis” or “vulva tuberculosis” AND “tuberculosis” AND “genital system” AND Persian keywords and similar search strategy in databases including PubMed, Scopus, Web of Sciences and in Iranian databases, such as Irandoc and Magiran during 2000-2021.
Results: Finally, 29 case reports articles, including 32 FGTP patients from around the world, were reviewed. Most of the patients (37.5%) were from India. An upper genital tuberculosis was more common in reproductive-age women, and the most involved upper genital organs were endometrium and fallopian tubes. In contrast, vulvar tuberculosis was more common in postmenopausal women, and the vulva was the most common site involved of lower genital tuberculosis. Weight loss (31.25%) and vaginal discharge (31.25%) were the most common symptoms reported by the study participants. The main histologic finding in female genital TB was the presence of epithelioid cell granulomas (81.25%). A total of 29 (90.6%) patients received the standard antibiotic therapy (combination of rifampicin, isoniazid, ethambutol, and pyrazinamide) and all of them responded well to treatment.
Conclusions: After the correct diagnosis of genital tuberculosis, most of the patients had a good response to treatment. We hope the results will be a significant guide in FGTP management, including early diagnosis, increasing clinical awareness, and improving treatment outcomes.
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Article Type: Original Research | Subject: General
Received: 2023/12/18 | Accepted: 2024/03/6 | Published: 2024/03/12

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