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Volume 5, Issue 3 (2024)
J Clinic Care Skill 2024, 5(3): 1001-1009 |
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Received: 2024/04/24 | Accepted: 2024/09/17 | Published: 2024/09/20
Received: 2024/04/24 | Accepted: 2024/09/17 | Published: 2024/09/20
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Abbasi larki R, Jahanbani S, Jannesar R, Manzoori L, Azad A. The Effect of Helicobacter Pylori Infection Eradication on Glomerular Filtration Rate in Patients with Chronic Kidney Disease. J Clinic Care Skill 2024; 5 (3) :1001-1009
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Abstract (50 Views)
Background: Concomitant Helicobacter pylori (H. pylori) infection in patients with chronic kidney disease (CKD) may increase the risk of progression to end stage renal disease.
Objective: We aimed to demonstrate whether eradication of this infection improves Glomerular Filtration Rate (GFR) in CKD patients.
Methods: This is across-sectional cohort study on 270 CKD patients with GFR between 30 to 60mL/min who were evaluated for H. pylori infection. A total of 79 patients were eligible for inclusion in the study. The patients underwent an early eradication treatment for H. pylori infection. The trend of changes in GFR was evaluated and compared in CKD patients in whome H. pylori infection was successfully eradicated (Group A) to those whose infection had not resolved (Group B) in a six month follow-up period.
Results: In total, 68 patients with CKD and a positive stool antigen test for H. pylori completed the study. When the mean GFR in CKD patients before and after treatment of H. pylori infection in the group A was compared, an upward trend was observed, increasing GFR from 44.6 ± 10.7 mL/min at baseline to 47.3 ± 13.6 mL/min at month 6 (P-value=0.3). Although the observed difference was not statistically significant (P-value=0.3), that of the group B has a downward trend during the study, decreasing from 46.6 ± 15.7 mL/min at baseline to 44.8 ± 14.3 mL/min at month 6.
Conclusion: H. pylori infection eradication in CKD patients increases the GFR and concurrent H. pylori infection and CKD may complicate
Objective: We aimed to demonstrate whether eradication of this infection improves Glomerular Filtration Rate (GFR) in CKD patients.
Methods: This is across-sectional cohort study on 270 CKD patients with GFR between 30 to 60mL/min who were evaluated for H. pylori infection. A total of 79 patients were eligible for inclusion in the study. The patients underwent an early eradication treatment for H. pylori infection. The trend of changes in GFR was evaluated and compared in CKD patients in whome H. pylori infection was successfully eradicated (Group A) to those whose infection had not resolved (Group B) in a six month follow-up period.
Results: In total, 68 patients with CKD and a positive stool antigen test for H. pylori completed the study. When the mean GFR in CKD patients before and after treatment of H. pylori infection in the group A was compared, an upward trend was observed, increasing GFR from 44.6 ± 10.7 mL/min at baseline to 47.3 ± 13.6 mL/min at month 6 (P-value=0.3). Although the observed difference was not statistically significant (P-value=0.3), that of the group B has a downward trend during the study, decreasing from 46.6 ± 15.7 mL/min at baseline to 44.8 ± 14.3 mL/min at month 6.
Conclusion: H. pylori infection eradication in CKD patients increases the GFR and concurrent H. pylori infection and CKD may complicate