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Volume 6, Issue 1 (2025)
J Clinic Care Skill 2025, 6(1): 1001-1010 |
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Ethics code: IR.YUMS.REC.1399.199
History
Received: 2025/01/21 | Accepted: 2025/03/18 | Published: 2025/01/29
Received: 2025/01/21 | Accepted: 2025/03/18 | Published: 2025/01/29
How to cite this article
Gholami D, Abbasi larki R, manzouri L, Taheri T, Asfaram A, Sadeghi Mansourkhani H et al . Oral supplementation with L-carnitine and omega-3 fatty acids improves lipid profiles and quality of life in renal failure patients receiving hemodialysis. J Clinic Care Skill 2025; 6 (1) :1001-1010
URL: http://jccs.yums.ac.ir/article-1-308-en.html
URL: http://jccs.yums.ac.ir/article-1-308-en.html
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Authors
D. Gholami1, R. Abbasi larki1, L. Manzouri2, T. Taheri3, A. Asfaram4, H. Sadeghi Mansourkhani *5, A. Dehghan6
1- Department of Nephrology, Yasuj University of Medical Sciences, Yasuj, Iran
2- Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3- Medical-Surgical Nursing Department, Nursing Faculty, Yasuj University of Medical Science, Yasuj, Iran
4- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
5- h_sadeghi_m@yahoo.com ,h_sadeghi_m@yahoo.com
6- Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
2- Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3- Medical-Surgical Nursing Department, Nursing Faculty, Yasuj University of Medical Science, Yasuj, Iran
4- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
5- h_sadeghi_m@yahoo.com ,
6- Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
Abstract (49 Views)
Aims : The objective of this study was to assess the effect of oral L –carnitine and omega 3 supplementations separately and in combination on lipid profile, ,CRP, QoL, QoS , questionnaires quality of life in a hemodialysis patient; questionnaires score of sleep quality (PSQI) in renal failure patients under hemodialysis.
Methods:A prospective cohort study was conducted on 75 hemodialysis patients divided into 3 groups (25) with randomized blocking. Intervention groups: 1) Use tab l carnitine 250mg twice a day, 2) Use 1 capsule omega3, 1000 mg a day, 3) Use tab l carnitine 250mg twice a day and 1 capsule omega3, 1000mg a day, for 3 months and assess KDQOL-SF, PSQI, lipid profile, and CRP before and after study, then analyzed by SPSS software using descriptive and inferential statistics.
Findings: The HDL level was significantly increased after the intervention compared to other groups. Moreover, in the L-carnitine and combination group, TG was significantly reduced compared to other groups. In the intervention combination group, CRP was significantly reduced compared to other groups that showed a decrease in inflammation. QoS improved in 3 groups but was not significantly different(p>0.05). Quality of life in renal failure patients under hemodialysis improved in combination and omega 3 groups( p<0.05).
Conclusion: l –carnitine and omega 3 supplementation improved sleep quality and public health-related quality of life in renal failure patients under hemodialysis.
Methods:A prospective cohort study was conducted on 75 hemodialysis patients divided into 3 groups (25) with randomized blocking. Intervention groups: 1) Use tab l carnitine 250mg twice a day, 2) Use 1 capsule omega3, 1000 mg a day, 3) Use tab l carnitine 250mg twice a day and 1 capsule omega3, 1000mg a day, for 3 months and assess KDQOL-SF, PSQI, lipid profile, and CRP before and after study, then analyzed by SPSS software using descriptive and inferential statistics.
Findings: The HDL level was significantly increased after the intervention compared to other groups. Moreover, in the L-carnitine and combination group, TG was significantly reduced compared to other groups. In the intervention combination group, CRP was significantly reduced compared to other groups that showed a decrease in inflammation. QoS improved in 3 groups but was not significantly different(p>0.05). Quality of life in renal failure patients under hemodialysis improved in combination and omega 3 groups( p<0.05).
Conclusion: l –carnitine and omega 3 supplementation improved sleep quality and public health-related quality of life in renal failure patients under hemodialysis.
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