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Volume 6, Issue 2 (2025)
J Clinic Care Skill 2025, 6(2): 1001-1016 |
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Ethics code: IR.YUMS.REC.1402.154
History
Received: 2025/05/20 | Accepted: 2025/06/8 | Published: 2025/04/30
Received: 2025/05/20 | Accepted: 2025/06/8 | Published: 2025/04/30
How to cite this article
Hashemiئohammadabad Z, Hashemimohammadabad M, Yazdanpanah I, Razmjoue D, Karimi F, Hashemimohammadabad N. The Effect of Deracocephalum Kotschyi Boiss or Melisa Officinalis on Depression in Patients with Depression. J Clinic Care Skill 2025; 6 (2) :1001-1016
URL: http://jccs.yums.ac.ir/article-1-397-en.html
URL: http://jccs.yums.ac.ir/article-1-397-en.html
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Authors
Z. Hashemiئohammadabad1, M. Hashemimohammadabad2, I. Yazdanpanah1, D. Razmjoue3, F. Karimi4, N. Hashemimohammadabad *5
1- College of Medicine, Zhejiang University of Medical Sciences, Zhejiang, China
2- College of Medicine, Zhengzhou University of Medical Sciences, Zhengzhou, China
3- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4- College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
5- College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran ,nazir.hashemi@gmail.com
2- College of Medicine, Zhengzhou University of Medical Sciences, Zhengzhou, China
3- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
4- College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
5- College of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran ,
Abstract (28 Views)
Materials & Methods This study was a quasi-experimental study with pre-test and post-test phases with 39 patients in 2023. In the control group, escitalopram (10 mg daily, single tablet) was prescribed for 30 days, and in the intervention group escitalopram (10 mg daily, single tablet) and melissa officinalis hydrochloride capsules (500 mg daily, single tablet) were prescribed for 30 days. Depression was measured by the Hamilton Depression Rating Scale and the Beck Depression Inventory. For the analysis of the data, chi-square test, paired t-tests and independent t-tests with significance of 0.05, SPSS version 26 were used.
Findings Seventy-eight participants were divided into two groups of 39. Regarding demographic variables, there was no statistically significant difference in treatment rates between the intervention and control groups. There was no significant difference between the two groups in severity of depression as measured by the Beck and Hamilton scales in pre-test (p=0.533, p=0.570). The severity of depression on the depression scale decreased significantly (p<0.001) in both groups in post-test, but the severity of depression on both scales decreased significantly (p<0.001) in the intervention group after intervention.
Conclusion Melisa Officinalis extract may be effective in reducing symptoms of depression when used in combination with the medicine escitalopram. However, to confirm this finding and to establish lemon balm as a new treatment option, larger, longer term clinical studies are needed to investigate the potential side effects and the exact mechanism of action of the product.
Findings Seventy-eight participants were divided into two groups of 39. Regarding demographic variables, there was no statistically significant difference in treatment rates between the intervention and control groups. There was no significant difference between the two groups in severity of depression as measured by the Beck and Hamilton scales in pre-test (p=0.533, p=0.570). The severity of depression on the depression scale decreased significantly (p<0.001) in both groups in post-test, but the severity of depression on both scales decreased significantly (p<0.001) in the intervention group after intervention.
Conclusion Melisa Officinalis extract may be effective in reducing symptoms of depression when used in combination with the medicine escitalopram. However, to confirm this finding and to establish lemon balm as a new treatment option, larger, longer term clinical studies are needed to investigate the potential side effects and the exact mechanism of action of the product.
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